Cincinnati Bengals vs. Jacksonville Jaguars
Sunday, 1 p.m. ET
FanDuel odds: Bengals -3.5, Total 49.5
Prediction: Bengals 30-23
Prop Pick: Bengals WR Ja’Marr Chase over 84.5 yards (-113 Bet365)
Chase was silent Week 1 (two catches, 26 yards). Last season he was held under 45 receiving yards twice. The two games after were a two-TD game vs. Washington (6-118) and a three-TD game at Baltimore (11-264).
Dallas Cowboys vs. New York Giants
Sunday, 1 p.m. ET
FanDuel odds: Cowboys -5.5, Total 44.5
Prediction: Cowboys 27-16
Prop Pick: Giants QB Russell Wilson over .5 interceptions (-115, BetMGM)
Wilson’s interception in Week 1 didn’t count. It was wiped out because of a roughing-the-passer penalty on former teammate Bobby Wagner. Dallas locked down the Eagles’ outside receivers in the opener and has a sticky-handed secondary that will make comeback mode a challenge if the Giants fall behind again.
Detroit Lions vs. Chicago Bears
Sunday, 1 p.m. ET
FanDuel odds: Lions -5.5, Total 46.5
Prediction: Lions 28-20
Prop Pick: Lions RB Jahmyr Gibbs 70-plus rushing yards plus anytime TD (+190, DraftKings)
Gibbs caught 10 passes last week and has been an animal at home. He also destroys the Bears. Gibbs had 975 yards from scrimmage (108.3 per game), 12 TDs (nine rushing) in nine home games last season. In four career games against the Bears, he has 435 total yards (108.8 per game) and three rushing touchdowns.
Tennessee Titans vs. Los Angeles Rams
Sunday, 1 p.m. ET
FanDuel odds: Rams -5.5, Total 41.5
Prediction: Rams 24-15
Prop Pick: Rams RB Kyren Williams over 74.5 rushing yards (-115, DraftKings)
Williams had at least 75 rushing yards in 10 games last season and is over 100 rushing yards in three consecutive road games.
Miami Dolphins vs. New England Patriots
Sunday, 1 p.m. ET
FanDuel odds: Dolphins -1.5, Total 43.5
Prediction: Dolphins 26-13
Prop Pick: Patriots WR Stefon Diggs over 41.5 receiving yards (-110, Caesars)
Diggs was targeted seven times and caught six passes Week 1, and the Dolphins allowed more than nine yards per dropback to the Colts in the opener. With Diggs working inside and second-year QB Drake Maye programmed not to hold the ball by offensive coordinator Josh McDaniels, this connection is very likely to be well-worn in Week 2.
New Orleans Saints vs. San Francisco 49ers
Sunday, 1 p.m. ET
FanDuel odds: 49ers -4.5, Total 41.5
Prediction: 49ers 23-10
Prop Pick: Saints TE Juwan Johnson over 33.5 receiving yards (-110, FanDuel)
Johnson hit the over on receptions and receiving yards nine times in the past 13 games. He caught eight passes for 76 yards in Week 1.
New York Jets vs. Buffalo Bills
Sunday, 1 p.m. ET
FanDuel odds: Bills -6.5, Total 46.5
Prediction: Bills 26-22
Prop Pick: Bills QB Josh Allen over 5.5 rushing attempts (-120, FanDuel)
Allen has gone over his rushing total projection in six consecutive road games, and the Jets are committed to man coverage. RB James Cook came out of the Sunday night win banged up and Allen ran nine times with a TD at the Jets in 2024.
Pittsburgh Steelers vs. Seattle Seahawks
Sunday, 1 p.m. ET
FanDuel odds: Steelers -2.5, Total 39.5
Prediction: Steelers 22-17
Prop Pick: Seahawks RB Zach Charbonnet anytime TD (+220, FanDuel)
Pittsburgh’s 17 missed tackles were the worst in the NFL in Week 1, and the Jets steamrolled the Steelers’ run defense all day long to be in position to pull the upset. There’s no fear of Sam Darnold tucking the ball to run, but Seattle does have an RB tandem to move the chains. Charbonnet shares time with Kenneth Walker but is the best option when Seattle needs to pick up hard yards. He scored his 10th career rushing touchdown last week.
Baltimore Ravens vs. Cleveland Browns
Sunday, 1 p.m. ET
FanDuel odds: Ravens -10.5, Total 44.5
Prediction: Ravens 35-17
Prop Pick: Ravens TE Mark Andrews anytime TD (+165, )
Baltimore led the NFL with 17 red-zone TD passes in 2024. Andrews caught TD passes in both games against the Browns last season and hit Cleveland with a two-TD game in 2023. With all the focus on hemming in QB Lamar Jackson and handling RB Derrick Henry, Andrews is a great prop target Sunday. An Andrews parlay of over 3.5 receptions and 40.5 yards plus a touchdown is worth contemplation.
Indianapolis Colts vs. Denver Broncos
Sunday, 4:05 p.m. ET
FanDuel odds: Broncos -1.5, Total 41.5
Prediction: Broncos QB Bo Nix over 34 pass attempts (+121, DraftKings)
Prop Pick: Nix attempted 40 passes last week and while he was miserable against the blitz and turned the ball over three times, coach Sean Payton doesn’t change his stripes. He’ll blend the running game, but the ball will be in the hands of the quarterback again this week.
Arizona Cardinals vs. Carolina Panthers
Sunday, 4:05 p.m. ET
FanDuel odds: Cardinals -6.5, Total 45.5
Prediction: Cardinals 33-18
Prop Pick: Panthers RB Chuba Hubbard over 61.5 rushing yards (-115 at ESPNBet)
Hubbard hammered the Cardinals for 152 yards on 25 carries last season in an overtime win against Arizona. No doubt Arizona is prepared for the plow horse approach from Carolina this week, but can they stop it? After giving up 126.4 yards per game rushing last season, they allowed 4.9 yards per carry at New Orleans in Week 1.
Kansas City Chiefs vs. Philadelphia Eagles
Sunday, 4:25 p.m. ET
FanDuel odds: Eagles -1.5, Total 46.5
Prediction: Eagles 31-23
Prop Pick: Chiefs QB Patrick Mahomes over 235.5 yards (-112, BetMGM)
Mahomes might not have his preferred pecking order at wide receiver, and Xavier Worthy was the biggest threat to Philadelphia in the Super Bowl loss. Even if Worthy isn’t on the field, the Chiefs have to like what they saw out of the Dallas downfield passing game. Dak Prescott was a couple CeeDee Lamb drops from a 300-plus yard game in the opener and Mahomes had more than 235.5 yards in 10 games last season with the same mishmash receiving corps questions.
Minnesota Vikings vs. Atlanta Falcons
Sunday, 8:20 p.m. ET
FanDuel odds: Vikings -4.5, Total 45.5
Prediction: Vikings 26-23
Prop Pick: Falcons RB Bijan Robinson over 3.5 receptions (-110, Bet365)
Robinson caught six passes for 100 yards in Week 1,and if Drake London (shoulder) winds up missing time or being limited Sunday night, his 15 targets are going to be spread around with backs picking up more target share. Noteworthy value on Robinson at +146 for five-plus catches was also available at FanDuel. If you can get a good number on Falcons WR Ray-Ray McCloud, he caught eight passes for 98 yards with a season-high 11 receptions at Minnesota in December 2024.
Tampa Bay Buccaneers vs. Houston Texans
Monday, 7 p.m. ET
FanDuel odds: Texans -2.5, Total 42.5
Prediction: Texans 26-19
Prop Pick: Texans RB Nick Chubb longest run under 13 yards (-110, DraftKings)
Broken tackles and yards after contact are the route to success for Chubb. The Buccaneers wrapped up Robinson (12 carries, 24 yards) last week and Falcons’ running backs had a long gain of six yards.
Los Angeles Chargers vs. Las Vegas Raiders
Monday, 10 p.m. ET
FanDuel odds: Chargers -3, Total 46.5
Prediction: Chargers 27-13
Prop Pick: Raiders QB Geno Smith over 244.5 passing yards (-114 FanDuel)
Until Ashton Jeanty gets more consistent alleys to attack, the plan for defenses was set by the Patriots last week: stack the box and shoot gaps to make Smith complete short, quick passes all the way down the field. The over of 31.5 pass attempts is equally inviting, but value is short at -140 at FanDuel.
