San Francisco 49ers coach Kyle Shanahan said quarterback Brock Purdy and tight end George Kittle will return to practice on Wednesday as limited participants.Purdy has missed four of the past five games due to a turf toe injury initially sustained in t...

49ers fans don't deserve this. A die hard fan base that has been to the brink of football immortality four times in the last six seasons simply doesn't deserve to endure a second straight campaign of historically bad injury luck. The feeling that the faithful, as well as the Niners' sideline and front office, experienc...

San Francisco wide receiver Jauan Jennings has been playing with five broken ribs as well as ankle and shoulder injuries, he told reporters after the 49ers' 30-19 loss to the host Tampa Bay Buccaneers on Sunday.Jennings, who has missed two games for th...

Baker Mayfield passed for 256 yards and two touchdowns, and Kameron Johnson and Tez Johnson each made their first career touchdown catches to help the host Buccaneers record a 30-19 victory over the banged-up San Francisco 49ers on Sunday.Rachaad White...

San Francisco 49ers star linebacker Fred Warner was carted off the field midway through the first quarter of Sunday's road game against the Tampa Bay Buccaneers with a potentially serious right lower-leg injury.Warner was defending a running play when ...

San Francisco 49ers safety Malik Mustapha is set to make his season debut Sunday against the Tampa Bay Buccaneers after he was activated from the physically unable to perform list following a knee injury.The 49ers also elevated defensive lineman Trevis...

San Francisco quarterback Brock Purdy will miss his second straight game and fourth in the past five due to his turf toe injury when the 49ers visit the Tampa Bay Buccaneers on Sunday.Purdy was initially injured during the season-opening game against t...

San Francisco 49ers general manager John Lynch said on Thursday that he is "fairly confident" that All-Pro tight end George Kittle will practice next week.Kittle has been on injured reserve since hurting his hamstring in the season opener and has misse...

Baker Mayfield is flirting with becoming a full-fledged MVP candidate as he leads the Tampa Bay Buccaneers into Sunday's contest against the visiting San Francisco 49ers.Meanwhile, San Francisco is just trying to keep its quarterbacks healthy.Brock Pur...

San Francisco 49ers quarterback Brock Purdy missed practice Wednesday and backup Mac Jones was limited while dealing with two injuries.Purdy missed three of the past four games with a turf toe issue and his availability for Sunday's game at the Tampa B...